UDP-glucose glycoprotein glucosyltransferase 2 (UGGT2)

UDP-glucose glycoprotein glucosyltransferase 2 (UGGT2) is an ER-resident glucosyltransferase and quality control sensor protein. It selectively reglucosylates misfolded N-glycoproteins, enabling their reassociation with lectin chaperones which retain them in the ER and facilitate further folding attempts or target them for degradation if proper folding is not restored. Unlike its paralogue UGGT1, which modifies a broader range of glycoproteins including large plasma membrane proteins, UGGT2 is preferentially active against smaller soluble lysosomal proteins. The function of UGGT2 is essential in maintaining secretory pathway integrity, and its misregulation has been linked to protein folding diseases. No approved drugs currently target UGGT2 directly, but its activity is critical for the proper folding and quality control of many secreted and lysosomal proteins, and thus indirectly relevant to the efficacy and safety of therapeutic biologics.

Other names

UGCGL2UGT2hUGT2FLJ11485HUGT2FLJ10873MGC150689MGC87276MGC117360UDP--Glc:glycoprotein glucosyltransferase 2UDP-glucose ceramide glucosyltransferase-like 1UDP-glucose ceramide glucosyltransferase-like 2

Putative inhibitors or modulators would affect ER quality control and glycoprotein maturation (no known drugs)