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Target intelligence / Profile preview
UDP-glucose pyrophosphorylase (UGP)
- Target
- UGP
- Molecular classification
- Enzyme
01
Overview
UDP-glucose pyrophosphorylase (UGP, also known as UGP2 in humans) is a key metabolic enzyme that catalyzes the reversible formation of UDP-glucose and pyrophosphate from glucose-1-phosphate and UTP. This reaction is Mg²⁺-dependent and is central to carbohydrate metabolism. It provides UDP-glucose—a critical precursor for glycogen synthesis, sucrose synthesis, lipopolysaccharide core biosynthesis, and cell wall polysaccharide production. In pancreatic ductal adenocarcinoma (PDAC), high expression of UGP2 supports tumor growth. Targeting this enzyme could have implications for cancer therapy and antifungal drug development.
- Other names
- UGP2
02
Mechanism of action
Inhibition of UDP-glucose pyrophosphorylase activity to disrupt glycogen synthesis and glycosylation.
03
Biological functions
Carbohydrate metabolismGlycogen synthesisGlycoprotein biosynthesisLipopolysaccharide biosynthesisCell wall polysaccharide production
04
Disease associations
Cancer
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