UDP-glucuronosyltransferase 1A3 (UGT1A3)

UDP-glucuronosyltransferase 1A3 is an enzyme that catalyzes glucuronidation, the process of attaching glucuronic acid to small lipophilic molecules—including hormones, bilirubin, steroids, and a wide variety of drugs—thus increasing their water solubility and promoting excretion via urine or bile. This is a critical pathway in phase II drug metabolism and detoxification of both endogenous and exogenous compounds. UGT1A3 is primarily expressed in the liver and is one of several related enzymes encoded by the UGT1A gene locus, each with distinct substrate specificities due to differences in the first exon. Mutations and expression differences in UGT1A3 can influence drug efficacy, pharmacokinetics, and the risk of adverse drug reactions

Other names

UGT1A3UDPGTUDP-glucuronosyltransferase 1-3UGT-1CUGT1-03UGT1.3UGT1CUGT1A3SUDPGT 1-3UDP glucuronosyltransferase family 1 member A3

Phase II conjugation: Drugs binding to and being conjugated by UGT1A3 are rendered more water-soluble, promoting their excretion via urine or bile. Inactivation or detoxification: Some drugs are inactivated or rendered less toxic through glucuronidation by UGT1A3