UDP-glucuronosyltransferase 1A5 (UGT1A5)

UDP-glucuronosyltransferase 1A5 (UGT1A5) is an enzyme involved in the glucuronidation pathway, a critical phase II metabolic process that attaches glucuronic acid to small lipophilic molecules such as drugs, steroids, bilirubin, and hormones, to render them more water-soluble for excretion via urine or bile[1][2][4][6][7]. UGT1A5 is one of several isoforms generated from a complex locus with multiple first exons spliced to common exons, each variant conferring different substrate specificity via its unique N-terminus[1][2]. This enzyme is essential for detoxification and elimination of various xenobiotics and endogenous compounds; alterations in its activity can impact drug metabolism and susceptibility to certain metabolic disorders—such as Crigler-Najjar syndrome and hyperbilirubinemia[1][2][6][7].

Other names

UDP-glucuronosyltransferase 1A5UGT1A5UDP glucuronosyltransferase 1 family, polypeptide A5UGT1*5UGT1-05UGT1.5UGT-1EUGT1EUDPGT 1-5UDP-glucuronosyltransferase 1 family polypeptide A5

Catalyzes the conjugation of glucuronic acid to a wide variety of endogenous and exogenous substances, aiding in their solubilization and excretion[1][7]