Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
UDP-glucuronosyltransferase 2A3 (UGT2A3)
- Target
- UGT2A3
- Molecular classification
- Enzyme, Transferase, Phase II drug-metabolizing enzyme
01
Overview
UGT2A3 is a membrane-bound phase II drug-metabolizing enzyme that catalyzes the glucuronidation of various lipophilic substrates to facilitate their elimination. It contains distinct substrate-binding and UDP-glucuronic acid-binding domains and can form oligomeric complexes that modulate enzymatic activity. The enzyme plays a crucial role in xenobiotic metabolism and drug clearance pathways.
- Other names
- UDP glucuronosyltransferase family 2 member A3UDP-glucuronosyltransferase 2A3UNQ2559/PRO6239UDPGT 2A3FLJ21934UDP glucuronosyltransferase 2 family polypeptide A3
02
Mechanism of action
Glucuronidation conjugation reaction
03
Biological functions
Xenobiotic metabolic processDrug metabolismPhase II biotransformationGlucuronidation
04
Disease associations
Drug metabolism disordersXenobiotic toxicity
05
Safety considerations
Genetic deficiency can cause increased blood concentration of substrate compounds
Beyond the preview
Go deeper on UDP-glucuronosyltransferase 2A3 (UGT2A3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on UDP-glucuronosyltransferase 2A3 (UGT2A3).