UDP-glucuronosyltransferase 2B17 (UGT2B17)

UDP-glucuronosyltransferase 2B17 (UGT2B17) is a human enzyme of the UDP-glucuronosyltransferase family, classified as a phase II metabolism enzyme that catalyzes the conjugation of glucuronic acid to diverse small molecules including steroid hormones (such as androgens and estrogens), drugs, and xenobiotics to facilitate their excretion[1][3][4]. UGT2B17 plays an essential role in drug detoxification, steroid regulation, and the metabolism of exogenous compounds; genetic variation in UGT2B17, particularly gene deletion, is associated with variability in drug metabolism and disease risk, including osteoporosis and altered responses to hormone therapies[1][3][4].

Other names

C19-steroid-specific UDP-glucuronosyltransferaseC19-steroid-specific UDPGTUDPGT 2B17UDP-glucuronosyltransferase family 2 member B17UGT2B17UDPGT2B17BMND12UDP-glucuronosyltransferase 2 family polypeptide B17UDP glycosyltransferase 2 family member B17UDP-glucuronyltransferase, family 2, beta-17

Catalyzes the glucuronidation (conjugation with glucuronic acid) of lipophilic substrates, facilitating their solubility and excretion