UDP-glucuronosyltransferase 2B28 (UGT2B28)

UDP-glucuronosyltransferase 2B28 is an enzyme of the glycosyltransferase 1 family, coded by the UGT2B28 gene and primarily found in the endoplasmic reticulum of steroidogenic tissues. It catalyzes the transfer of glucuronic acid to a broad range of lipophilic substrates—including steroid hormones (such as androgens and estrogens), bile acids, and xenobiotics—via glucuronidation, a key phase II metabolic process for detoxification and elimination. Beyond its enzymatic role, UGT2B28 is functionally implicated in modulating androgen and lipid signaling, especially in prostate cancer, where its expression is associated with tumor progression and is influenced by androgen receptor activity. UGT2B28 also participates in feedback loops in steroid metabolism, and evidence suggests it may serve as a biomarker for disease aggressiveness and therapeutic response in androgen-driven cancers[1][2][3][5][7].

Other names

UDP glucuronosyltransferase family 2 member B28UDP-glucuronosyltransferase 2B28UDPGT 2B28UDP glucuronosyltransferase 2 family, polypeptide B28UDP glycosyltransferase 2 family, polypeptide B28

For drugs/substrates: glucuronidation—conjugation with glucuronic acid, increasing water solubility and facilitating excretion. Potential indirect modulation of androgen signaling via enzyme regulatory roles and heterodimerization with other UGTs, blocking clearance of active androgens in cancer.