UDP-glucuronosyltransferase 2B4 (UGT2B4)

UDP-glucuronosyltransferase 2B4 (UGT2B4) is a membrane-bound phase II drug-metabolizing enzyme predominantly found in the liver and to a lesser extent in other tissues. It catalyzes the glucuronidation (a form of conjugation) of bile acids (notably hyodeoxycholic acid), catechol-estrogens, steroids, bilirubin, and a wide variety of xenobiotics and drugs. This glucuronidation process generally enhances the solubility of these molecules, facilitating their elimination from the body. UGT2B4 activity and expression are regulated by several nuclear receptors (including FXR and PPARα). Genetic variability in UGT2B4 can impact individual responses to medications and susceptibility to toxicity, and altered UGT2B4 function may have relevance in diseases such as hormone-dependent cancers and liver disorders[1][2][3][4][5].

Other names

UDP-glucuronosyltransferase 2B4UGT2B4UGT2B11UDPGT 2B4HLUG25Hyodeoxycholic acid-specific UDPGTUDPGTh-1UDPGT2B4UDPGTH1UDP glucuronosyltransferase 2 family, polypeptide B4UDP-glucuronyltransferase, family 2, beta-4hyodeoxycholic acid-specific UDPGT

Facilitates the conjugation of glucuronic acid to substrates possessing suitable functional groups (e.g., hydroxyl, carboxylic acid, amine, thiol), increasing solubility and promoting renal or biliary excretion[1][2][3]