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Target intelligence / Profile preview
UDP-N-acetylenolpyruvoylglucosamine Reductase (MurB)
- Target
- MurB
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) is an essential bacterial enzyme that catalyzes a crucial step in peptidoglycan biosynthesis, specifically the NADPH-dependent reduction of UDP-N-acetylenolpyruvoylglucosamine to UDP-N-acetylmuramic acid. As this pathway is absent in mammals, MurB is an attractive target for antibacterial drug development.
- Other names
- UDP-N-acetylmuramate dehydrogenaseMurB reductaseUDP-N-acetylglucosamine-enoylpyruvate reductaseUridine diphosphoacetylpyruvoylglucosamine reductase
02
Mechanism of action
Inhibition of bacterial cell wall synthesis
03
Biological functions
CatalysisPeptidoglycan biosynthesisCell wall biosynthesisAminosugar metabolism
04
Disease associations
InfectionBacterial infection
05
Safety considerations
Potential for off-target effects in the gut microbiomeDevelopment of bacterial resistance
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