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Target intelligence / Profile preview
UDP-N-acetylenolpyruvylglucosamine reductase (MurB)
- Target
- MurB
- Molecular classification
- Enzyme, oxidoreductase
01
Overview
UDP-N-acetylenolpyruvylglucosamine reductase, also known as MurB, is an enzyme involved in the biosynthesis of peptidoglycan, a critical component of bacterial cell walls. It catalyzes the reduction of UDP-N-acetylenolpyruvylglucosamine to UDP-N-acetylmuramic acid, a step necessary for peptidoglycan synthesis. This enzyme is considered a therapeutic target for developing antibacterial agents due to its essential role in bacterial cell wall formation and the lack of a homologue in eukaryotic cells.
- Other names
- UDP-N-acetylmuramate dehydrogenase1.3.1.98yijB
02
Mechanism of action
Inhibitors of this enzyme would prevent the synthesis of UDP-N-acetylmuramic acid, which is essential for bacterial cell wall formation.
03
Biological functions
Cell wall formationpeptidoglycan biosynthesis
04
Disease associations
Infection (target for antibacterial agents)
05
Safety considerations
Targeting this enzyme could lead to specific concerns related to its role in bacterial cell walls.
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