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Target intelligence / Profile preview
UDP-N-acetylglucosamine enolpyruvyl transferase (MurA)
- Target
- MurA
- Molecular classification
- Enzyme, Transferase
01
Overview
UDP-N-acetylglucosamine enolpyruvyl transferase, commonly known as MurA, is a key bacterial enzyme that catalyzes the first committed step in peptidoglycan biosynthesis. Peptidoglycan is an essential component of the bacterial cell wall, making MurA a critical target for antibacterial drug development. Inhibition of MurA disrupts cell wall synthesis leading to bacterial death, it remains an attractive target for novel antibacterial agents.
- Other names
- UDP-N-acetylglucosamine 1-carboxyvinyltransferasePyruvate-UDP-acetylglucosamine transferaseEnolpyruvyl transferase (EPT)
02
Mechanism of action
Fosfomycin acts as a covalent inhibitor of MurA by modifying an active site cysteine residue, thereby blocking its enzymatic activity.
03
Biological functions
Peptidoglycan biosynthesisCell wall synthesis
04
Disease associations
Infection
05
Safety considerations
Development of resistance
06
Interacting drugs
Fosfomycin
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