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UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD)
- Target
- MurD
- Molecular classification
- Enzyme, Ligase
01
Overview
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) is a cytoplasmic enzyme essential for bacterial cell wall biosynthesis. It catalyzes the addition of D-glutamate to UDP-N-acetylmuramoyl-L-alanine, forming part of the peptidoglycan precursor pathway. This step is crucial for bacterial cell wall integrity, making it a validated target for antibacterial drug development.
- Other names
- MurD synthetaseUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetaseD-glutamate-adding enzymeD-glutamate ligase
02
Mechanism of action
Inhibition of peptidoglycan biosynthesis
03
Biological functions
Peptidoglycan biosynthesisD-glutamine and D-glutamate metabolismCell wall formation
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects in bacteriaDevelopment of resistance
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