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Target intelligence / Profile preview
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (MurF)
- Target
- MurF
- Molecular classification
- Enzyme, Ligase
01
Overview
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (MurF) is an essential bacterial enzyme involved in the biosynthesis of peptidoglycan, a critical component of the bacterial cell wall. It catalyzes the final step in the formation of UDP-N-acetylmuramoyl-pentapeptide, which serves as a precursor for murein (peptidoglycan) synthesis. MurF is responsible for catalyzing the ATP-dependent addition of D-Ala–D-Ala dipeptide to UDP-N-acetylmuramoyl-tripeptide during peptidoglycan biosynthesis. The activity of MurF is crucial for maintaining cell wall integrity and thus bacterial viability. It is an attractive target for antibacterial drug development due to its essential role and lack of human homologs.
- Other names
- MurF synthetaseUridine diphosphoacetylmuramoylpentapeptide synthetaseUDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase
02
Mechanism of action
Inhibition of peptidoglycan biosynthesis
03
Biological functions
Peptidoglycan biosynthesisLysine biosynthesisCell wall synthesis
04
Disease associations
Infection
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