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Target intelligence / Profile preview
UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD)
- Target
- MurD
- Molecular classification
- Enzyme, Ligase
01
Overview
UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) is a bacterial enzyme essential for peptidoglycan biosynthesis, catalyzing the ATP-dependent addition of D-glutamic acid to UDP-N-acetylmuramoyl-L-alanine. This step is crucial for bacterial cell wall integrity. MurD is comprised of three domains and is absent in mammals, making it a promising target for antibacterial drug development. Inhibitors targeting MurD disrupt peptidoglycan synthesis, leading to bacterial cell death.
- Other names
- MurD synthetaseUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseD-glutamate-adding enzymeD-glutamate ligase
02
Mechanism of action
Enzyme inhibition of peptidoglycan synthesis
03
Biological functions
Peptidoglycan biosynthesisD-glutamine and D-glutamate metabolism
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects in bacteriaDevelopment of bacterial resistance
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