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UDP-sugar transporter protein SLC35A5 (SLC35A5)
- Target
- SLC35A5
- Molecular classification
- Transporter, Solute carrier (SLC) family, Nucleotide sugar transporter (NST)
01
Overview
UDP-sugar transporter protein SLC35A5 is a member of the solute carrier family 35 subfamily A and encodes a probable nucleoside-sugar transporter that localizes to the Golgi apparatus and endoplasmic reticulum[1][2][8]. It functions as a transmembrane antiporter involved in transporting UDP-alpha-D-glucuronate (UDP-GlcA), UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), and UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) from the cytosol into the lumen of the Golgi by exchanging them for UMP[2][3][8]. These activities are essential for proper glycosylation of proteins and lipids, a fundamental biochemical process across many tissues[1][3]. Mutations or dysfunction in SLC35A5 are associated with congenital disorders of glycosylation and some neurodevelopmental conditions[3]. There are no known drugs directly targeting SLC35A5, and it is primarily studied as a transporter relevant to glycosylation metabolism.
- Other names
- Solute carrier family 35 member A5S35A5UNQ164/PRO190FLJ20730probable UDP-sugar transporter protein SLC35A5
02
Biological functions
Nucleotide-sugar transmembrane transport[2][3][8]UDP-sugar:UMP antiport (exchange transport of UDP-activated sugars for UMP)[2][3][8]Supports glycosylation processes in the Golgi apparatus and endoplasmic reticulum[1][3]
03
Disease associations
Congenital disorder of glycosylation (Type IIm)[3]Developmental and epileptic encephalopathy[3]
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