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Target intelligence / Profile preview
Ultra Rapid Delayed Rectifier Potassium Current (IKur)
- Target
- IKur
- Molecular classification
- Ion channel, Voltage-gated potassium channel, Kv channel, Kv1 family, Kv1.5 channel
01
Overview
The ultra rapid delayed rectifier potassium current (IKur) is a specific type of voltage-gated potassium current found predominantly in atrial myocytes of the heart. It is primarily mediated by the Kv1.5 channel (encoded by the KCNA5 gene). IKur contributes to phase 1 and early phase 3 repolarization of the atrial action potential, which helps sets the refractory period and overall excitability of atrial cells. IKur's presence leads to a more triangular-shaped action potential waveform and shorter duration of action potentials in atria compared to ventricles. Selective blockade has been proposed as an antiarrhythmic strategy that targets only atria, potentially reducing pro-arrhythmic risk for ventricles.
- Other names
- Ultra rapid delayed rectifier K+ currentKv1.5-mediated K+ current
02
Mechanism of action
IKur blockade
03
Biological functions
Cardiac action potential repolarizationRegulation of atrial excitabilitySetting atrial refractory period
04
Disease associations
Atrial fibrillationArrhythmia
05
Safety considerations
Potential for pro-arrhythmic effects (though atrial-selective blockers aim to minimize ventricular effects)Action potential duration changesDrug interactions
06
Interacting drugs
Vernakalant
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