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Target intelligence / Profile preview
Ultrarapid delayed rectifier potassium current (IKur)
- Target
- IKur
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
The IKur potassium channel refers to the ultrarapid delayed rectifier potassium current, a major repolarizing current in the human atrium. It is primarily formed by Kv1.5 subunits encoded by the KCNA5 gene. IKur plays a critical role in shaping the cardiac action potential, particularly during the early phase of repolarization in atrial myocytes. Its atrial-specific expression makes it a target for developing atria-selective antiarrhythmic drugs.
- Other names
- Kv1.5 potassium channelKCNA5 channel
02
Mechanism of action
IKur channel blockade
03
Biological functions
Cardiac repolarizationRegulation of atrial action potential durationPotassium ion transmembrane transport
04
Disease associations
Atrial fibrillationCardiovascular disease
05
Safety considerations
Potential for proarrhythmic effects if ventricular repolarization is affectedComplex effects on APD depending on underlying electrical remodeling
06
Interacting drugs
4-aminopyridine
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