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The phrase "ultrasound imaging enhancement via acoustic impedance difference" refers to the improvement of ultrasound image quality by utilizing the physical property known as acoustic impedance. Acoustic impedance is defined as the product of a tissue's density and the speed of sound through that tissue (Z = ρc). The amount of ultrasound wave reflected at a tissue interface is determined by the difference in acoustic impedance between adjacent tissues; larger differences produce stronger echoes, which result in more visible boundaries and structures on ultrasound images[1][2][3][4][5][7][9]. This principle is fundamental to the physics of ultrasound imaging but does not relate to a druggable or therapeutic target.
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