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Target intelligence / Profile preview
UMODL1 antisense RNA 1 (UMODL1-AS1)
- Target
- UMODL1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
UMODL1 antisense RNA 1 (UMODL1-AS1) is a long non-coding RNA gene located on human chromosome 21. It produces an antisense RNA transcript complementary to the UMODL1 gene, with regulatory potential in cell biology. Although it does not encode a protein, UMODL1-AS1 has been studied as a molecular biomarker: its expression and methylation status correlate with kidney function and several cancers, most notably non-small cell lung cancer and triple-negative breast cancer. UMODL1-AS1 does not appear to be a direct therapeutic target but may play a role in gene regulation, with clinical interest focused on its utility as a diagnostic or prognostic marker rather than as a modulator of signaling, metabolism, or transport.
- Other names
- C21orf128FLJ33471UMODL1 antisense gene protein 1Uncharacterized protein UMODL1-AS1UMODL1 antisense RNA 1UMODL1-AS1
02
Biological functions
Possible regulation of UMODL1 gene expressionPutative involvement in gene regulation via lncRNA mechanismsImplicated in cellular processes relevant to disease, including cancer and kidney function
03
Disease associations
Cancer prognosis and modification, including non-small cell lung cancer and triple-negative breast cancerBiomarker for chronic kidney disease and renal function
04
Biomarkers
Expression levels associated with kidney function (eGFR)Expression and methylation associated with cancer prognosis (lung cancer, triple-negative breast cancer)
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