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Target intelligence / Profile preview
unc-13 homolog D (Munc13-4)
- Target
- Munc13-4
- Molecular classification
- Other
01
Overview
UNC13D (unc-13 homolog D) encodes the protein Munc13-4, a member of the UNC13 family. This protein plays a critical role in immune cell function, particularly in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. The primary function of Munc13-4 is to regulate the exocytosis of cytolytic granules—specialized vesicles containing proteins that induce target cell death—by facilitating their maturation, docking, priming, and fusion with the plasma membrane at immunological synapses. Mutations or deficiencies in UNC13D cause severe immune dysregulation, notably Familial Hemophagocytic Lymphohistiocytosis Type 3 (FHL3).
- Other names
- FHL3HLH3HPLH3UN13D_HUMAN
02
Mechanism of action
N/A
03
Biological functions
Exocytosis of cytolytic granulesRegulation of immune responsesVesicle traffickingSNARE complex interaction
04
Disease associations
Familial Hemophagocytic Lymphohistiocytosis Type 3 (FHL3)Macrophage activation syndromeSystemic juvenile idiopathic arthritis (SJIA)
05
Safety considerations
Uncontrolled activation/proliferation of immune cellsExcessive cytokine release (cytokine storm)Tissue damage
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