Unc-5 homolog C-like protein (UNC5CL)

Unc-5 homolog C-like protein (UNC5CL) is a human protein encoded by the UNC5CL gene on chromosome 6. It shows peptidase activity and is involved in the positive regulation of the JNK cascade and canonical NF-kappaB signaling, where it reportedly inhibits NF-kappaB-dependent transcription by preventing NF-kappaB from binding to DNA targets[1][9][4][8]. It is expressed in the cytosol, centrosome, and membrane, with tissue distribution notably in the gastrointestinal tract and kidney[1][7]. Disease relevance is suggested by an association with cardia cancer, though its characterization as a classical drug target (such as a receptor or enzyme with validated therapeutic ligands) is currently lacking[1][7][9]. The protein may also participate in the netrin signaling pathway and has been annotated with peptidase and potentially netrin receptor molecular activities but remains insufficiently characterized as a therapeutic target[1][4][9].

Other names

UNC5CLZUDMGC34763MUXAZU5 and death domain-containing proteinProtein unc-5 homolog C-likeunc-5 family C-terminal likeZU5 and death domain containing