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Target intelligence / Profile preview
Unc-5 Netrin Receptor B (UNC5B)
- Target
- UNC5B
- Molecular classification
- Receptor, Netrin Receptor, Dependence Receptor
01
Overview
UNC5B (Unc-5 Netrin Receptor B) is a receptor for netrin-1, mediating repulsive guidance cues during nervous system development and playing key roles in vascular biology and apoptosis. It functions as a dependence receptor, inducing apoptosis when not bound to netrin. UNC5B is involved in axon repulsion, negatively regulates angiogenesis, and its dysregulation is linked to hyperinsulinemic hypoglycemia, epilepsy, and cancer. It is expressed across various tissues, including the brain, peripheral organs, and immune-related tissues.
02
Mechanism of action
N/A
03
Biological functions
Axon guidance (repulsion)Negative regulation of angiogenesisApoptosis induction without ligandCell migrationMorphogenesis
04
Disease associations
Hyperinsulinemic Hypoglycemia Familial 3EpilepsyCancerNervous system development disorders
05
Safety considerations
Potential for pro-apoptotic activity in the absence of ligandComplex role in cancer progression (tumor suppressor vs. oncogene)
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