Unc-50 inner nuclear membrane RNA-binding protein (UNC50)

Unc-50 inner nuclear membrane RNA-binding protein (UNC50) is a conserved transmembrane protein localized to the inner nuclear membrane and is characterized by its capacity to bind RNA via an amino-terminal RNA recognition-like motif[1][2]. It is widely expressed in mammalian tissues, especially in brain, kidney, and testis. UNC50 plays a role in the cell surface expression of neuronal nicotinic receptors, likely by participating in their intracellular trafficking or assembly, although the protein has broader evolutionary conservation, being found in organisms without nicotinic receptors[1][2]. Current data do not support its role as a direct therapeutic target or disease biomarker, and there are no reported interacting drugs or established safety considerations.

Other names

Protein unc-50 homologUNCLHSD-23HSD23PDLs22hGMH1URPGMH1Periodontal ligament-specific protein 22Protein GMH1 homologUncoordinated-like proteingeal-6 membrane-associated high-copy suppressor 1unc-50 relatedunc-50-like protein