Unc-93 homolog B1 (UNC93B1)

UNC93B1 (not "UNC93B3" or "UNC93B3P") is a polytopic transmembrane protein located in the endoplasmic reticulum that is essential for the proper functioning of intracellular Toll-like receptors (TLRs), specifically TLR3, TLR7, TLR9, and TLR13[1]. It facilitates the trafficking and signaling of these TLRs by directly interacting with them through their transmembrane domains in immune cells such as dendritic cells and macrophages. Mutations in UNC93B1 (such as H412R) impair these interactions and result in severe defects in the signaling of these TLRs, leading to a compromised innate immune response to pathogens[1]. **Clarifications:** - The target name "UNC93B3" or "Unc-93 homolog B3" (also "UNC93B3P") is not present as a well-established, canonical human gene or protein. The established gene/protein relevant to innate immunity, TLR trafficking, and disease is called **UNC93B1 (Unc-93 homolog B1)**, typically abbreviated as **UNC93B1** or sometimes as **UNC93B**[1]. - "UNC93B3," "UNC93B3P," or "Unc-93 homolog B3" likely arises from annotation of *pseudogenes* or confusion with isoforms that do not code for a protein or are not recognized as meaningful targets in molecular biology or drug discovery. There is no evidence for "UNC93B3" being a functional protein or recognized target. **Summary:** - The function, targetability, and disease relationships described in immunology literature refer to **UNC93B1**, not "UNC93B3"[1]. - There are no drugs, mechanisms of action, or biomarkers tied to "UNC93B3," and safety/therapeutic information applies only to the true protein, UNC93B1. **Conclusion:** The query as stated is incorrect (`is_incorrect: true`), because "UNC93B3" or "UNC93B3P" does not appear to be a valid or recognized molecular target. The proper entity is UNC93B1 ("Unc-93 homolog B1"), essential for innate immune receptor signaling[1].

Other names

UNC93BUnc93 homolog B1UNC93B1Unc-93 homolog B (C. elegans)Unc93b