Uncharacterized protein KIAA0040 (KIAA0040)

Uncharacterized protein KIAA0040 is encoded by the KIAA0040 gene on human chromosome 16. Although originally annotated as a protein of unknown function, recent studies show it is highly expressed in glioma and other cancers, and promotes glioma cell proliferation, invasion, and migration primarily through activation of the JAK2/STAT3 signaling pathway. KIAA0040 overexpression is associated with tumor progression, elevated cell cycle activity, reduced apoptosis, and poor patient prognosis in glioma. KIAA0040 is also cited in disease association with alcoholism and myoclonic juvenile epilepsy, although its mechanistic role is less clear outside oncology. The molecule is regarded as a potential therapeutic target in glioma, particularly via inhibition of its downstream signaling pathways[1][3]. No approved drugs target KIAA0040 directly, but inhibitors of JAK2/STAT3 (e.g., Bosutinib) attenuate its oncogenic effects in preclinical models[1]. Its functional family, domain structure, and physiological roles beyond cancer are not fully established, classifying it as "Other" in molecular classification and "uncharacterized" in protein databases[2][3].

Other names

KIAA0040Uncharacterized protein KIAA0040

Modulation of JAK2/STAT3 pathway (activation by KIAA0040 increases signaling, promoting cell proliferation and migration, inhibition with Bosutinib reverses these effects)