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Target intelligence / Profile preview
Unconventional myosin-Id (MYO1D)
- Target
- MYO1D
- Molecular classification
- Motor protein, Actin-associated motor protein, Other (Class I unconventional myosin)
01
Overview
Unconventional myosin-Id (**MYO1D**) is a class I myosin motor protein that binds to actin filaments and utilizes ATP hydrolysis to generate movement along the actin cytoskeleton. MYO1D is expressed in multiple tissues, with important roles in **cellular membrane trafficking** and the regulation of **myelin formation and maintenance** in the central nervous system, particularly in oligodendrocytes. It is also a key determinant of **biological chirality** (left-right asymmetry) at cellular and organismal levels, with evidence from model organisms showing that MYO1D can induce dextral (right-sided) twisting, affecting the anatomical and behavioral asymmetry of developing tissues and organs. Although MYO1D is involved in fundamental processes such as cytoskeletal organization and developmental asymmetry, it is not currently classified as a direct therapeutic target, and no drugs are known to specifically modulate its function.
- Other names
- Myosin IDMyosin 1DMYO1DKIAA0727MYR4Protein phosphatase 1 regulatory subunit 108 (PPP1R108)Myosin-I gammaUnconventional myosin-Id
02
Biological functions
Actin filament bindingMicrofilament motor activityDetermination of left/right (L/R) symmetryMembrane traffickingMyelin formation and maintenanceChirality induction at the cellular and organismal level
03
Disease associations
Developmental disorders involving L/R asymmetry (based on evidence in Drosophila and vertebrates)Other (no robust disease associations established in humans; research in animal models suggests roles in body plan asymmetry)
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