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Target intelligence / Profile preview
Uncoordinated 51-like kinase 4 (URLC10)
- Target
- URLC10
- Molecular classification
- GPI-linked surface glycoprotein, Ly6/uPAR superfamily member, Cancer-testis antigen
01
Overview
Uncoordinated 51-like kinase 4 (URLC10), also known as Lymphocyte antigen 6 complex locus K (LY6K), is a GPI-anchored cell surface glycoprotein belonging to the Ly6/uPAR superfamily. It exhibits restricted normal tissue expression (primarily testis) and is frequently upregulated in various cancers, making it a cancer-testis antigen. LY6K plays roles in cell growth regulation, sperm motility, and tumorigenesis by promoting cancer cell proliferation and potentially contributing to immune evasion. It is a therapeutic target for peptide vaccines aimed at inducing cytotoxic T lymphocyte responses against tumor cells.
- Other names
- Lymphocyte antigen 6 complex locus KLY6KCO16CT97ly-6KHSJ001348
02
Mechanism of action
Induction of cytotoxic T lymphocyte responses against tumor cells expressing LY6K; Inhibition of ERK signaling and cell cycle progression
03
Biological functions
Cell growth regulationSperm motilityTumorigenesisCell proliferationCell cycle progressionImmune evasion
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to limited normal tissue expressionImmune-related adverse events associated with peptide vaccination
06
Interacting drugs
Peptide vaccines (e.g., URLC10-derived peptides)
1 more in the full profile.
07
Biomarkers
LY6K expression level in tumor tissueHLA restriction for peptide vaccine efficacy
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