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Uncoupling Protein 2 (UCP2)
- Target
- UCP2
- Molecular classification
- Mitochondrial Anion Carrier Protein (MACP), Uncoupling Protein, Transporter
01
Overview
Uncoupling Protein 2 (UCP2) is a mitochondrial inner membrane protein that belongs to the uncoupling protein family. It facilitates the regulated discharge of protons across the inner mitochondrial membrane, uncoupling oxidative phosphorylation from ATP synthesis. UCP2 primarily functions to regulate mitochondria-derived reactive oxygen species (ROS), protecting cells from oxidative stress. Alterations in UCP2 expression or function have been linked to cardiovascular diseases, metabolic disorders, and neurodegenerative diseases.
02
Mechanism of action
Modulates mitochondrial proton gradient and reactive oxygen species (ROS) production; acts as an anion antiporter.
03
Biological functions
Proton transportAnion transportRegulation of reactive oxygen species (ROS)Modulation of ATP synthesisCalcium homeostasisRegulation of lipid metabolism
04
Disease associations
Cardiovascular diseasesMetabolic disordersNeurodegenerative diseasesObesity-related complications
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