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Target intelligence / Profile preview
Undecaprenyl phosphate recycling (C55-P Recycling)
- Target
- C55-P Recycling
- Molecular classification
- Lipid metabolism, Enzyme complex, Membrane transport
01
Overview
Undecaprenyl phosphate (UndP or C55-P) recycling is an essential process in bacteria involving the dephosphorylation and translocation of C55-PP to regenerate active C55-P, which is critical for cell wall synthesis. Inhibition of this process leads to accumulation of intermediates and cessation of peptidoglycan assembly, making it an attractive target for antibiotic development. Bacitracin inhibits this cycle.
- Other names
- Bactoprenol phosphate recyclingUndP RecyclingC55-phosphate cycle
02
Mechanism of action
Inhibition of undecaprenyl phosphate dephosphorylation, sequestration of undecaprenyl pyrophosphate
03
Biological functions
Cell wall biosynthesisLipid carrier recyclingMembrane transport of saccharidesPeptidoglycan synthesis
04
Disease associations
Bacterial infections
05
Safety considerations
Potential for off-target effects on lipid metabolismDevelopment of bacterial resistance
06
Interacting drugs
Bacitracin
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