Target intelligence / Profile preview

Undecaprenyl pyrophosphate (C55-PP)

Target
C55-PP
Molecular classification
Lipid carrier, Lipid, Isoprenoid
01

Overview

Undecaprenyl pyrophosphate (C55-PP) is an essential lipid carrier molecule in bacteria, playing a critical role in cell wall biosynthesis. It transports peptidoglycan precursors and other polysaccharides across the cytoplasmic membrane. After delivering its cargo, it is dephosphorylated to undecaprenyl phosphate (C55-P) for recycling. Inhibition of this cycle disrupts peptidoglycan synthesis and is a target for antibiotic development.

Other names
C55-isoprenyl pyrophosphateUndecaprenyl diphosphateall-trans-undecaprenyl diphosphatebactoprenyl pyrophosphateC55-Isoprenyl-pyrophosphatUndPPPyrophosphoryl undecaprenol
02

Mechanism of action

Inhibition of cell wall synthesis by targeting undecaprenyl pyrophosphate cycle

03

Biological functions

Peptidoglycan synthesisCell wall biosynthesisMembrane transport
04

Disease associations

Infection
05

Safety considerations

Potential for off-target effects due to structural similarities with eukaryotic isoprenoids

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