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Target intelligence / Profile preview
Undecaprenyl Diphosphate Synthase (UppS)
- Target
- UppS
- Molecular classification
- Enzyme, Prenyltransferase, cis-Prenyltransferase
01
Overview
Undecaprenyl diphosphate synthase (UppS/UPPS) is an essential bacterial enzyme responsible for producing C55-lipid carriers needed during peptidoglycan synthesis—a process absent from human biology—making it a validated target for new antibacterial agents designed to combat resistant pathogens by disrupting their ability to build functional cell walls without affecting human cells directly.
- Other names
- UPPSUndecaprenyl Pyrophosphate SynthaseC55-PP synthase
02
Mechanism of action
Inhibition of undecaprenyl diphosphate synthesis, disruption of peptidoglycan synthesis, bacterial cell lysis
03
Biological functions
Lipid biosynthesisPeptidoglycan biosynthesisCell wall biosynthesisProduction of undecaprenyl diphosphate (C55-PP)
04
Disease associations
InfectionBacterial infection
05
Safety considerations
Potential for off-target effects in beneficial bacteria
06
Interacting drugs
Bis-amidines
7 more in the full profile.
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