Target intelligence / Profile preview

Unfractionated Heparin (UFH)

Target: UFH
Molecular classification: Glycosaminoglycan, Anticoagulant

Overview

Unfractionated heparin (UFH) is a naturally occurring, heterogeneous mixture of sulfated glycosaminoglycans used as an anticoagulant. It acts primarily by potentiating antithrombin III’s inhibition of key coagulation enzymes. Its clinical utility lies in its rapid onset but requires careful monitoring due to variability in response and significant risks including bleeding complications and HIT. Its effects can be rapidly reversed if needed.

Other names: HeparinHigh Molecular Weight Heparin (HMWH)

Mechanism of action

Binds to and activates antithrombin III, which then inhibits thrombin (Factor IIa) and Factor Xa, thereby preventing clot formation.

Biological functions

AnticoagulationInhibition of blood coagulation cascadeActivation of antithrombin III

Disease associations

ThrombosisPulmonary embolismCardiovascular diseaseThromboembolic disorders

Safety considerations

Bleeding complicationsHeparin-induced thrombocytopenia (HIT)Osteoporosis (with long-term use)Heparin resistanceHypersensitivity reactions

Interacting drugs

Protamine sulfate

4 more in the full profile.

Biomarkers

aPTT (activated partial thromboplastin time)Anti-Xa activity

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