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Unknown Prostamide Receptor
- Molecular classification
- Receptor, G protein-coupled receptor (GPCR) - hypothesized
01
Overview
The prostamide receptor is a hypothesized receptor believed to mediate the biological effects of prostamides. Despite extensive pharmacological evidence for its existence, the gene and protein structure of this receptor have not been identified. It is functionally defined by its response profile to prostamides and related compounds like bimatoprost, and it can be blocked by antagonists like AGN 204396 and AGN 211334. Current research focuses on identifying the gene and protein structure of this elusive receptor.
02
Mechanism of action
Agonism/antagonism at the unknown prostamide receptor
03
Biological functions
Signal transductionRegulation of intraocular pressureModulation of aqueous humor dynamics
04
Disease associations
Glaucoma
05
Safety considerations
Unknown due to lack of molecular characterization. Safety concerns related to drugs interacting with this receptor are known, such as those associated with bimatoprost (e.g., ocular side effects).
06
Interacting drugs
Bimatoprost
2 more in the full profile.
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