Unknown senescence-related molecular targets

The term 'Unknown senescence-related molecular targets' refers to a broad and evolving category of molecular markers and therapeutic vulnerabilities in senescent cells that have not yet been fully characterized or identified as specific drug targets. Cellular senescence is a state of permanent cell cycle arrest that contributes to aging and age-related diseases through the secretion of pro-inflammatory factors, collectively known as the senescence-associated secretory phenotype (SASP). While several targets such as BCL-2, p16INK4a, and p21WAF1/CIP1 are well-established in the field of senolytics, research continues to uncover novel pathways that could be exploited to selectively eliminate senescent cells or modulate their harmful effects. This generic designation highlights the ongoing search for specific, druggable proteins that can serve as therapeutic anchors without affecting healthy tissue homeostasis. Consequently, this entry does not represent a single, well-defined therapeutic target but rather a research area focused on identifying new drivers of the senescent phenotype.

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