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Up-regulated lung cancer 10
- Molecular classification
- Ly6/uPAR superfamily, Glycosylphosphatidylinositol (GPI)-anchored protein
01
Overview
LY6K is a GPI-anchored protein belonging to the Ly6/uPAR superfamily. It is highly expressed in testis and is crucial for male fertility. LY6K is also strongly upregulated in various cancers, including lung cancer and glioblastoma, promoting tumor cell proliferation, metastasis, and immune evasion. It enhances ERK1/2 signaling via interaction with caveolin-1. LY6K is considered a potential biomarker and therapeutic target for several cancers due to its upregulation correlating with disease progression and poor prognosis.
- Other names
- Lymphocyte antigen 6 complex, locus KLY6KURLC10
02
Mechanism of action
Inhibition of directed migration of tumor cells; Modulation of immune checkpoints (PD-L1/PD-1); Interference with ERK1/2 signaling
03
Biological functions
Sperm motilityFertilityTumor cell proliferationMetastasisImmune evasionERK1/2 signaling regulation
04
Disease associations
Lung CancerGlioblastomaInfertility
05
Safety considerations
Potential impact on fertility due to its role in sperm functionOff-target effects on immune cells
06
Biomarkers
LY6K expression levels in tumors
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