UPK3BL-RASA4 readthrough transcript (ENSG00000205236)

The "UPK3BL-RASA4 readthrough" (ENSG00000205236) is a predicted gene fusion transcript resulting from a readthrough event between the adjacent UPK3BL and RASA4 genes on chromosome 7. Readthrough transcripts generally arise from transcription extending beyond the normal termination site of one gene into a neighboring gene. These transcripts are often annotated by automated genome annotation projects but rarely encode functional or physiologically relevant proteins, and there is no evidence in the published literature supporting a biological function or disease relevance for this specific readthrough. The component genes have known functions: RASA4 encodes a Ras GTPase-activating protein involved in signal transduction pathways, while UPK3BL is a poorly characterized gene of the uroplakin family. However, the fused readthrough product itself is not established as a functional protein, receptor, or therapeutic target. These types of predicted or computational transcripts are generally excluded from lists of valid molecular drug targets.

Other names

UPK3BL-RASA4 readthroughENSG00000205236May appear with Ensembl or NCBI gene IDs as alternative names