Upstream binding transcription factor, RNA polymerase I-like 3 (pseudogene) (UBTFL3)

UBTF like 3 (UBTFL3) is annotated as a pseudogene in the human genome (GeneID: 129870)[3][7]. This locus is predicted to be a non-functional remnant of gene duplication or retrotransposition and does not produce a functional protein. The gene is described as containing a high mobility group (HMG) box motif, but unlike its functional counterparts (such as UBTF), it has no known biological activity, protein product, or therapeutic relevance. The functional gene UBTF (upstream binding transcription factor) encodes a transcription factor that binds ribosomal DNA and is critical for ribosomal RNA transcription by RNA polymerase I, but UBTFL3 itself is not a functional transcription factor[3][4][6]. Key distinctions: UBTF like 3 (UBTFL3) should not be confused with the upstream binding transcription factor (UBTF), which is a biologically active protein involved in transcription regulation[5]. UBTFL3 is not a therapeutic target, has no protein product, is not part of any known disease mechanism, and is not referenced as a biomarker or involved in any drug interactions[3][7].

Other names

UBTFL3UBTFL5HMG box-containing protein LOC129870putative upstream-binding factor 1-like protein 3/5upstream binding transcription factor, RNA polymerase I-like 3 (pseudogene)