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Target intelligence / Profile preview
Uric Acid (N/A)
- Target
- N/A
- Molecular classification
- Small Molecule, Purine Metabolite, Endogenous Metabolite
01
Overview
Uric acid is the final product of purine metabolism in humans. Elevated levels in the blood (hyperuricemia) can lead to gout and kidney stones, while low levels have been linked to neurological disorders. It acts as an antioxidant at lower concentrations but exhibits pro-inflammatory effects at higher concentrations.
- Other names
- Urate7,9-Dihydro-1H-purine-2,6,8(3H)-trione2,6,8-Trioxopurine
02
Mechanism of action
Uric acid itself is not directly targeted by drugs. Interacting drugs target the enzyme xanthine oxidase (e.g., allopurinol, febuxostat) to reduce uric acid production or promote its excretion (e.g., probenecid, lesinurad). Pegloticase converts uric acid to allantoin.
03
Biological functions
Purine MetabolismAntioxidant (at low concentrations)Pro-inflammatory (at high concentrations)
04
Disease associations
GoutKidney StonesHyperuricemiaChronic Kidney DiseaseNeurological Disorders (e.g., Multiple Sclerosis)Cardiovascular DiseaseMetabolic Syndrome
05
Safety considerations
Hyperuricemia can lead to gout and kidney stones.Hypouricemia can be associated with neurological disorders.
06
Interacting drugs
Allopurinol
3 more in the full profile.
07
Biomarkers
Serum uric acid levels (diagnosis and monitoring of gout and hyperuricemia)
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