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URB1 antisense RNA 1 (URB1-AS1)
- Target
- URB1-AS1
- Molecular classification
- Other (Long non-coding RNA)
01
Overview
URB1 antisense RNA 1 (URB1-AS1) is a long non-coding RNA (lncRNA) located on chromosome 12 or 21, described as an antisense transcript to the URB1 locus[1][2]. It does not encode a protein but is involved in the regulation of gene expression through ceRNA mechanisms and transcriptional modulation. URB1-AS1 has been implicated in cellular processes such as proliferation, apoptosis, and migration. Its dysregulation has been reported in various cancers, where it may function either as a tumor promoter or suppressor depending on context. Its complex and context-dependent roles are still under investigation, and it is not currently considered a conventional therapeutic target such as a receptor, enzyme, or transporter[2].
- Other names
- C21orf119PRED84MGC14136URB1 antisense gene protein 1
02
Mechanism of action
Acts as a competing endogenous RNA (ceRNA) sponging microRNAs, regulation of gene expression at the transcriptional level[2]
03
Biological functions
Cell proliferationApoptosisCell migrationRegulation of gene expression
04
Disease associations
Cancer (including breast, lung, colorectal, gastric, and hepatocellular carcinoma)Other
05
Biomarkers
Potential prognostic biomarker in several cancers
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