URB2 ribosome biogenesis homolog (URB2)

URB2 ribosome biogenesis homolog (**URB2**) is a protein involved in the critical process of ribosome biogenesis in eukaryotic cells, specifically participating in the processing of 27S pre-rRNA and the biogenesis of the large (60S) ribosomal subunit[2][3][6]. It is highly expressed during hematopoietic stem cell expansion and plays an essential role in supporting the proliferation and survival of these cells by regulating ribosome assembly and protein synthesis through the p53 pathway in specific biological contexts, such as in zebrafish hematopoiesis[1][2]. URB2 is classified as a **ribosome biogenesis factor**, not as a receptor, enzyme, transporter, or transcription factor. Mutations or deficiencies in URB2 can impair stem cell development and are associated with disrupted ribosome assembly, connecting it to disorders known as ribosomopathies (such as some bone marrow failure syndromes)[1][2]. There is currently no known drug that targets URB2, it is not established as a therapeutic target in pharmacology, and there are no validated biomarkers or specific safety concerns directly tied to its modulation. This entry refers to the human gene URB2, with high sequence conservation across eukaryotes[3][5].

Other names

Unhealthy ribosome biogenesis protein 2 homologRibosome biogenesis protein Urb2