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Urea Transporter (UT)
- Target
- UT
- Molecular classification
- Membrane Transport Protein, Transporter
01
Overview
Urea transporters (UTs) are integral membrane proteins that facilitate the rapid, passive movement of urea across biological membranes. They are crucial for urine concentration and water balance, particularly in the kidney. The main human UTs are encoded by the SLC14A1 (UT-B isoforms) and SLC14A2 (UT-A isoforms) genes. Inhibition of UT activity represents a potential strategy for developing novel diuretics.
- Other names
- SLC14A1SLC14A2UT-AUT-BUrea transporter protein
02
Mechanism of action
Inhibition of urea transport, leading to increased diuresis and reduced reabsorption of urea-driven water movement.
03
Biological functions
Urea transportUrine concentrationWater balanceUrea recycling
04
Disease associations
HypertensionFluid overloadDisorders involving water homeostasis
05
Safety considerations
Electrolyte imbalance (potential if diuretic effect is too strong)Off-target effects due to broad tissue distribution of UT isoforms
06
Interacting drugs
Thioureas
1 more in the full profile.
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