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Target intelligence / Profile preview
Urea Transporter Protein (UT)
- Target
- UT
- Molecular classification
- Transporter
01
Overview
Urea transporter proteins (UTs) are integral membrane proteins that facilitate the rapid and selective transport of urea across biological membranes. They play a crucial role in maintaining urea homeostasis, particularly in the kidney for urine concentration. Multiple isoforms exist, including UT-A (kidney) and UT-B (erythrocytes). Topically applied urea leverages UTs' humectant and keratolytic properties, enhancing skin hydration and breaking down hyperkeratotic skin.
- Other names
- Urea transporterUT-AUT-B
02
Mechanism of action
Facilitated diffusion of urea; disrupts intercellular matrix components in hyperkeratotic skin.
03
Biological functions
Urea transportUrea homeostasisWater balanceSkin hydration (humectant)Keratolysis
04
Disease associations
Kidney diseasePsoriasisIchthyosisHyperkeratosis
05
Interacting drugs
Urea (topical)
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