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Uric Acid Degradation Bifunctional Protein (None)
- Target
- None
- Molecular classification
- Enzyme, Oxidase
01
Overview
The uric acid degradation bifunctional protein, commonly known as urate oxidase or uricase, is a key enzyme in the purine catabolic pathway. It catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further degraded to allantoin—a more water-soluble compound that can be easily excreted from the body. This enzymatic activity is crucial for maintaining low levels of uric acid and preventing its accumulation. In humans loss of the enzyme's activity leads to increased risk for gout and other hyperuricemia-related pathologies, therefore recombinant forms are used as therapeutics.
- Other names
- Urate OxidaseUricase
02
Mechanism of action
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further degraded to allantoin
03
Biological functions
CatalysisUric acid degradationPurine metabolism
04
Disease associations
GoutHyperuricemiaTumor lysis syndromeKidney stonesHypertensionInsulin resistance
05
Safety considerations
Immunogenicity of recombinant enzymesInfusion reactionsAnaphylaxisGout flare during initial treatment
06
Interacting drugs
Rasburicase
1 more in the full profile.
07
Biomarkers
Uric acid levels
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