Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Uric Acid Transporter 1 (URAT1)
- Target
- URAT1
- Molecular classification
- Transporter, Solute Carrier, Organic Anion Transporter (OAT), SLC22 Family
01
Overview
Uric Acid Transporter 1 (URAT1), encoded by the SLC22A12 gene, is a key transporter protein located in the apical membrane of proximal tubule cells in the kidney. It mediates the reabsorption of uric acid from the renal filtrate back into the bloodstream, playing a critical role in maintaining systemic uric acid homeostasis. URAT1 functions as an antiporter, exchanging intracellular organic anions for extracellular urate. Its dysfunction or overactivity contributes to hyperuricemia and gout, making it a validated target for anti-gout therapies. Inhibitors of URAT1 promote urinary excretion of uric acid, lowering serum uric acid levels.
- Other names
- SLC22A12
02
Mechanism of action
Inhibition of uric acid reabsorption in the kidney, leading to increased urinary excretion of uric acid.
03
Biological functions
Uric acid reabsorptionRegulation of serum urate levelsAnion exchange
04
Disease associations
HyperuricemiaGoutCardiovascular disease (related to hyperuricemia)Metabolic diseases (related to hyperuricemia)
05
Safety considerations
Drug interactionsAdverse effects of urate-lowering therapiesPotential for kidney stones (with increased uric acid excretion)
06
Interacting drugs
Probenecid
5 more in the full profile.
07
Biomarkers
Serum uric acid levelsUrinary uric acid excretion
Beyond the preview
Go deeper on Uric Acid Transporter 1 (URAT1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Uric Acid Transporter 1 (URAT1).