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Target intelligence / Profile preview
Uridine-cytidine kinase 1 (UCK1)
- Target
- UCK1
- Molecular classification
- Enzyme, Kinase, Nucleoside kinase, Transferase
01
Overview
Uridine-cytidine kinase 1 is a cytoplasmic enzyme that phosphorylates uridine and cytidine to form uridine monophosphate and cytidine monophosphate, using ATP or GTP as phosphate donors. It specifically does not phosphorylate deoxyribonucleosides or purine ribonucleosides, but can modify certain nucleoside analogs, which is important for the activation of some chemotherapeutic agents. UCK1 is expressed broadly across human tissues and is implicated in nucleotide salvage pathways and the metabolism of fluoropyrimidine drugs; alteration in its activity is associated with cancer and drug response.
- Other names
- UCK1URK1FLJ12255Cytidine monophosphokinase 1Uridine monophosphokinase 1
02
Mechanism of action
Drugs interact as substrates, undergoing phosphorylation by UCK1 to active monophosphate forms crucial for their cytotoxic or therapeutic effect.
03
Biological functions
Nucleotide salvagePhosphorylation of uridine and cytidineMetabolism of nucleoside analogsPrecursor activation for DNA/RNA biosynthesisInvolvement in fluoropyrimidine metabolism pathways
04
Disease associations
Cancer (notably lung oat cell carcinoma)Muscular dystrophy, congenital, type 1BOther diseases where nucleotide metabolism or analogs are implicated
05
Safety considerations
Potential toxicity from off-target phosphorylation of nucleoside analogsResistance mechanisms in cancer can involve loss or downregulation of UCK1
06
Interacting drugs
Nucleoside analog drugs such as 5-fluorouridine and 5-fluorocytidine (used in chemotherapy)
3 more in the full profile.
07
Biomarkers
Expression of UCK1 (and functional activity) may serve as a biomarker to predict the efficacy of nucleoside analog chemotherapy (e.g., response to fluoropyrimidines)
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