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Uridine Metabolism (None)

Target: None
Molecular classification: Metabolic Pathway

Overview

Uridine metabolism refers to the biological processes involved in the synthesis, degradation, and interconversion of uridine—a pyrimidine nucleoside essential for various cellular functions. Uridine is a key metabolite found in plasma and cerebrospinal fluid. It plays pivotal roles in nucleic acid synthesis, glycogen synthesis (via UDP-glucose), protein modification (through O-GlcNAcylation), and regulation of metabolic rate and gene expression. Disrupted uridine homeostasis has been linked with various metabolic and neurological diseases.

Biological functions

Nucleotide biosynthesisEnergy homeostasisGlucose homeostasisLipid homeostasisAmino acid homeostasisProtein modification

Disease associations

Diabetes mellitusNeurodegenerative disordersFatty liver diseaseObesityTumorigenesis

Biomarkers

Uridine levels

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