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Uridine Phosphorylase (UPase)
- Target
- UPase
- Molecular classification
- Enzyme, Glycosyltransferase, Pentosyltransferase
01
Overview
Uridine phosphorylase (UPase, EC 2.4.2.3) is an enzyme that catalyzes the reversible phosphorolysis of uridine to uracil and alpha-D-ribose 1-phosphate. It belongs to the glycosyltransferase family and plays a central role in pyrimidine metabolism by participating in the salvage pathway for pyrimidine nucleosides. Its activity is often elevated in various tumor tissues, enhancing sensitivity to chemotherapeutic agents like 5-FU. Inhibitors of UP or genetic disruption can modulate drug toxicity profiles or rescue normal tissues from chemotherapeutic side effects.
- Other names
- Pyrimidine phosphorylaseUrdPaseUPHUPuridine:phosphate alpha-D-ribosyltransferase
02
Mechanism of action
Phosphorolysis of uridine to uracil and alpha-D-ribose 1-phosphate; activation of fluoropyrimidines.
03
Biological functions
Pyrimidine metabolismPyrimidine salvageNucleotide biosynthesisNucleotide degradationRegulation of fluoropyrimidine activation
04
Disease associations
Cancer
05
Safety considerations
Modulation of fluoropyrimidine toxicityChemotherapeutic side effects
06
Interacting drugs
5-Fluorouracil (5-FU)
2 more in the full profile.
07
Biomarkers
UP expression levels in tumor tissue
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