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Target intelligence / Profile preview
Urocortin-2 Analog (UCN2 Analog)
- Target
- UCN2 Analog
- Molecular classification
- Peptide, CRH family peptide, Receptor agonist
01
Overview
Urocortin-2 analogs are synthetic or modified versions of urocortin-2 (UCN2), a 38-amino acid peptide and selective agonist for the corticotropin-releasing factor type 2 receptor (CRF2). These analogs are designed to mimic or enhance the biological activity of native UCN2, often with improved pharmacokinetic properties. They are being explored for therapeutic applications including obesity, heart failure and muscle wasting disorders.
- Other names
- Urocortin II AnalogCRF2 agonist analogsCRHR2 agonist analogs
02
Mechanism of action
Selective agonism of the corticotropin-releasing factor type 2 receptor (CRHR2), leading to activation of the cAMP/PKA signaling pathway, Akt, and ERK1/ERK2 pathways.
03
Biological functions
VasodilationAnorexigenic effectMuscle hypertrophyCardiac contractilityDelayed gastric emptying
04
Disease associations
ObesityDiabetes mellitusChronic kidney diseaseHeart failureMuscle wasting disorders
05
Safety considerations
Arrhythmias (related to altered calcium fluxes in cardiac tissue at high doses)Potential for off-target effects due to structural similarity to other CRH family peptides
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