Target intelligence / Profile preview

Urokinase plasminogen activator (uPA)

Target: uPA
Molecular classification: Serine Protease, Enzyme

Overview

Urokinase plasminogen activator (uPA) is a serine protease that converts plasminogen into plasmin, a broad-spectrum protease involved in extracellular matrix (ECM) degradation, fibrinolysis, wound healing, and tissue remodeling. It plays a crucial role in cancer invasion and metastasis.

Mechanism of action

Inhibition of uPA activity

Biological functions

FibrinolysisWound healingTissue remodelingECM degradationCell migration

Disease associations

CancerMetastasis

Safety considerations

Potential for bleeding complications

Biomarkers

uPA levels in tissueuPAR levels in tissue

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