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Target intelligence / Profile preview
Urokinase Plasminogen Activator Receptor-Associated Protein (uPARAP)
- Target
- uPARAP
- Molecular classification
- Transmembrane endocytic receptor, Mannose receptor
01
Overview
Urokinase plasminogen activator receptor-associated protein (uPARAP), also known as Endo180 or mannose receptor, C type 2, is a 180-kDa transmembrane endocytic receptor. It mediates the binding, internalization, and degradation of collagen from the extracellular matrix, playing a crucial role in tissue remodeling, particularly in the lung. uPARAP is expressed in mesenchymal cells, especially fibroblasts, and its expression can be downregulated by cytokines such as TGFβ, TNFα, and IL‑1. It represents a potential therapeutic target for modulating fibrosis and abnormal tissue remodeling processes.
- Other names
- Endo180Mannose Receptor C Type 2MRC2
02
Mechanism of action
Modulation of collagen turnover through receptor-mediated endocytosis and degradation.
03
Biological functions
Collagen bindingCollagen internalizationCollagen degradationExtracellular matrix remodeling
04
Disease associations
FibrosisLung injuryTissue remodeling
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